Repaglinide (RPG) is a non-sulfonylurea oral hypoglycemic agent, mainly used in the management of type II diabetes mellitus. In the present work, a new attempt was made for formulation of mucoadhesive matrix tablets by using combination of tamarind seed powder as polymer and its methanolic and ethyl acetate extracts as super disintegrants for tablets. Tamarind seed is chiefly consisting of polysaccharides have the inherent characteristics of swelling, bioadhesion and good disintegrating properties. Hence an attempt was made to develop matrix tablets of repaglinide with tamarind seed powder and its extracts to check their influence on disintegration, swelling, bioadhesion and enhancing their release rate characteristics. Mucoadhesive matrix tablets with tamarind seed powder alone were extended the drug release for more than 12 hrs. Mucoadhesive matrix tablets with methanolic and ethyl acetate extract of tamarind seed powder alone release the drug within 1 hr, where as the combination of tamarind seed powder and it’s methanolic and ethyl acetate extracts extend the drug release for 12 hrs. Drug release from the tablets followed first order kinetics upto 85-90% release and the release was diffusion controlled. The mechanism of drug release was by non fickian diffusion. Tablets were evaluated for physical parameters, in-vitro dissolution studies, ex-vivo residence time, mucoadhesive strength, ex-vivo permeation studies and swelling index. The optimized inclusion complex and mucoadhesive tablet were evaluated by FTIR and DSC studies.
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